Featured
Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system
2024, PNAS
Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system
2024, PNAS

Liangliang Hao, Natalie Boehnke, Susanna K. Elledge, Nour-Saïda Harzallah, Renee T. Zhao, Eva Cai, Yu-Xiong Feng, Sofia Neaher, Heather E. Fleming, Piyush B. Gupta, Paula T. Hammond, and Sangeeta N. Bhatia

2024, PNAS
Inhalable point-of-care urinary diagnostic platform
2024, Science Advances
Inhalable point-of-care urinary diagnostic platform
2024, Science Advances

QIAN ZHONG, EDWARD K. W. TAN, CARMEN MARTIN-ALONSO, TIZIANA PARISI, LIANGLIANG HAO, JESSE D. KIRKPATRICK, TAREK FADEL, HEATHER E. FLEMING, TYLER JACKS, AND SANGEETA N. BHATIA

2024, Science Advances
Featured
CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
2023, Journal of Visualized Experiments
CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
2023, Journal of Visualized Experiments

Audrey E. Van Heest, Feiyang Deng, Renee T. Zhao, Nour Saida Harzallah, Heather E. Fleming, Sangeeta N. Bhatia, Liangliang Hao

2023, Journal of Visualized Experiments
Support strategies are needed for women in STEM with childcare responsibilities
2023, Nature Reviews Bioengineering
Support strategies are needed for women in STEM with childcare responsibilities
2023, Nature Reviews Bioengineering

Natalie Boehnke & Liangliang Hao

2023, Nature Reviews Bioengineering
CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics
Nature Nanotechnology, 2023
CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics
Nature Nanotechnology, 2023

Liangliang Hao, Renee T. Zhao, Nicole L. Welch, Edward Kah Wei Tan, Qian Zhong, Nour Saida Harzallah, Chayanon Ngambenjawong, Henry Ko, Heather E. Fleming, Pardis C. Sabeti & Sangeeta N. Bhatia

Nature Nanotechnology, 2023
Featured
Microenvironment-triggered multimodal precision diagnostics
Nature Materials, 2021
Microenvironment-triggered multimodal precision diagnostics
Nature Materials, 2021

Liangliang Hao, Nazanin Rohani, Renee T. Zhao, Emilia M. Pulver, Howard Mak, Olivia J. Kelada, Henry Ko, Heather E. Fleming, Frank B. Gertler & Sangeeta N. Bhatia

Nature Materials, 2021
Featured
Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing
Angewandte Chemie, 2020
Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing
Angewandte Chemie, 2020

Natalie Boehnke*, Santiago Correa*, Liangliang Hao*, Wade Wang, Joelle P. Straehla, Sangeeta N. Bhatia, Paula T. Hammond (*Contributed equally)

Angewandte Chemie, 2020
Cancer cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma.
Cancer Res., 2020
Cancer cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma.
Cancer Res., 2020

Chenxi Tian, Daniel Öhlund, Steffen Rickelt, Tommy Lidström, Ying Huang, Liangliang Hao, Renee T. Zhao, Oskar Franklin, Sangeeta N. Bhatia, David Tuveson, Richard Hynes

Cancer Res., 2020
Featured
Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer
Oncotarget., 2019
Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer
Oncotarget., 2019

Maud-Emmanuelle Gilles, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N Bhatia, Frank J Slack

Oncotarget., 2019
Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes
Cancer Res., 2019
Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes
Cancer Res., 2019

Nazanin Rohani, Liangliang Hao, Maria Alexis, Brian A. Joughin, Mira N. Moufarrej, Anthony Soltis, Shannon K. Hughes, Michael B. Yaffe, Douglas Lauffenburger, Christopher B. Burge, Sangeeta N. Bhatia, Frank Gertler

Cancer Res., 2019
Featured
iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer
Mol Cancer Ther., 2018
iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer
Mol Cancer Ther., 2018

Justin H. Lo*, Liangliang Hao*, Mandar D. Muzumdar, Srivatsan Raghavan, Ester J. Kwon, Emilia Pulver, Felicia Hsu, Andrew J. Aguirre, Brian M. Wolpin, Charles S. Fuchs, William C. Hahn, Tyler Jacks, Sangeeta N. Bhatia

Mol Cancer Ther., 2018
Personalized RNA-medicine for pancreatic cancer
Clin. Cancer Res., 2018
Personalized RNA-medicine for pancreatic cancer
Clin. Cancer Res., 2018

Maud-Emmanuelle Gilles, Liangliang Hao, Ling Huang, Rajesha Rupaimoole, Pedro P. Lopez-Casas, Emilia Pulver, Jong C. Jeong, Senthil K. Muthuswamy, Manuel Hidalgo, Sangeeta N. Bhatia and Frank J. Slack

Clin. Cancer Res., 2018
Featured
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8gene expression and restores enterocyte migration in LPS-induced septic mice
Sci. Rep., 2016
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8gene expression and restores enterocyte migration in LPS-induced septic mice
Sci. Rep., 2016

Xiao Wang, Liangliang Hao, Heng-Fu Bu, Ke Tian, Fangyi Liu, Isabelle De Plaen, Yulan Liu, Chad A. Mirkin, and Xiao-Di Tan

Sci. Rep., 2016
Featured
Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation
Small., 2015
Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation
Small., 2015

Chuan Zhang*, Liangliang Hao*, Colin M. Calabrese, Xiaochen A. Wu, Chad A. Mirkin

Small., 2015
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Genes Dev., 2015
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Genes Dev., 2015

Fotini M. Kouri, Lisa A. Hurley, Weston L. Daniel, Emily S. Day, Youjia Hua, Liangliang Hao, Chian-Yu Peng, Timothy J. Merkel, Markus A. Queisser, Carissa Ritner, Hailei Zhang, C. David James, Jacob I. Sznajder, Lynda Chin, David A. Giljohann, John A. Kessler, Marcus E. Peter, Chad A. Mirkin and Alexander H. Stegh.

Genes Dev., 2015
Featured
Spherical nucleic acids as a divergent platform for synthesizing RNA-nanoparticle conjugates through enzymatic ligation
ACS Nano, 2014
Spherical nucleic acids as a divergent platform for synthesizing RNA-nanoparticle conjugates through enzymatic ligation
ACS Nano, 2014

Jessica. L. Rouge, Liangliang Hao, Xiaochen. A. Wu, William E. Briley, Chad A. Mirkin

ACS Nano, 2014
Featured
Mechanism for the endocytosis of spherical nucleic acids nanoparticle conjugates
PNAS, 2013
Mechanism for the endocytosis of spherical nucleic acids nanoparticle conjugates
PNAS, 2013

Chung Hang J. Choi*, Liangliang Hao*, Suguna P. Narayan, Evelyn Auyeung, Chad A. Mirkin

PNAS, 2013
Featured
Antibody-Linked Spherical Nucleic Acids for Cellular Targeting
JACS, 2012
Antibody-Linked Spherical Nucleic Acids for Cellular Targeting
JACS, 2012

Ke Zhang*, Liangliang Hao*, Sarah J. Hurst, Chad A. Mirkin

JACS, 2012
Featured
Nucleic Acid–Gold Nanoparticle Conjugates as Mimics of microRNA
Small., 2011
Nucleic Acid–Gold Nanoparticle Conjugates as Mimics of microRNA
Small., 2011

Liangliang Hao,Pinal C. Patel,Ali H. Alhasan,David A. Giljohann,Chad A. Mirkin

Small., 2011